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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRRK2
All Species:
11.21
Human Site:
T838
Identified Species:
35.24
UniProt:
Q5S007
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5S007
NP_940980.3
2527
286103
T838
K
Q
T
N
I
A
S
T
L
A
R
M
V
I
R
Chimpanzee
Pan troglodytes
XP_001168494
2527
286042
T838
K
Q
T
N
I
A
S
T
L
A
R
M
V
I
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543734
2485
280928
T796
K
E
T
N
I
G
S
T
L
A
R
M
V
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q5S006
2527
284773
V838
K
Q
T
N
T
G
S
V
L
A
R
K
V
L
R
Rat
Rattus norvegicus
XP_235581
2526
284839
V837
K
Q
T
N
A
G
S
V
L
A
R
K
V
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667002
2157
241918
S672
S
W
I
S
A
L
L
S
E
R
R
S
Q
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392166
3008
340764
K894
Q
N
T
Y
Q
R
Y
K
D
S
S
G
E
F
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786899
2766
310174
S918
L
P
P
S
E
A
R
S
S
Q
G
L
N
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
N.A.
90.1
N.A.
86.6
86.5
N.A.
N.A.
N.A.
N.A.
42.6
N.A.
N.A.
20.4
N.A.
29.3
Protein Similarity:
100
99.5
N.A.
94
N.A.
93.1
93.4
N.A.
N.A.
N.A.
N.A.
59
N.A.
N.A.
38.5
N.A.
49.2
P-Site Identity:
100
100
N.A.
80
N.A.
66.6
66.6
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
6.6
N.A.
13.3
P-Site Similarity:
100
100
N.A.
93.3
N.A.
73.3
73.3
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
20
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
25
38
0
0
0
63
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% D
% Glu:
0
13
0
0
13
0
0
0
13
0
0
0
13
0
13
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
0
% F
% Gly:
0
0
0
0
0
38
0
0
0
0
13
13
0
13
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
13
0
38
0
0
0
0
0
0
0
0
25
0
% I
% Lys:
63
0
0
0
0
0
0
13
0
0
0
25
0
0
0
% K
% Leu:
13
0
0
0
0
13
13
0
63
0
0
13
0
38
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
38
0
0
0
% M
% Asn:
0
13
0
63
0
0
0
0
0
0
0
0
13
0
0
% N
% Pro:
0
13
13
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
13
50
0
0
13
0
0
0
0
13
0
0
13
0
0
% Q
% Arg:
0
0
0
0
0
13
13
0
0
13
75
0
0
0
75
% R
% Ser:
13
0
0
25
0
0
63
25
13
13
13
13
0
13
0
% S
% Thr:
0
0
75
0
13
0
0
38
0
0
0
0
0
0
13
% T
% Val:
0
0
0
0
0
0
0
25
0
0
0
0
63
0
0
% V
% Trp:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
13
0
0
13
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _